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Microtubule/Tubulin


Microtubules (micro- + tube + -ule) are a component of the cytoskeleton, found throughout the cytoplasm. They are found in eukaryotic cells, as well as some bacteria, and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. 
Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell and, together with microfilaments and intermediate filaments, they form the cytoskeleton. They also make up the internal structure of cilia and flagella.They provide platforms for intracellular transport and are involved in a variety of cellular processes, including the movement of secretory vesicles, organelles, and intracellular macromolecular assemblies. They are also involved in chromosome separation, and are the major constituents of mitotic spindles, which are used to pull apart eukaryotic chromosomes.
  • Vinblastine EY1699

    Vinblastine能抑制nAChR,IC50为8.9 uM,还能抑制微管形成。

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  • Vincristine EY1704

    Vincristine通过与微管蛋白结合而抑制微管聚合,IC50为32 μM。

    More
  • Nocodazole EY1163

    Nocodazole是一种微管聚合的快速可逆抑制剂,也抑制Abl, Abl(E255K)和Abl(T315I),IC50分别为0.21 μM, 0.53 μM和0.64 μM。

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  • Epothilone B EY0324

    Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.

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  • Fosbretabulin Disodium EY0295

    Combretastatin A4 disodium phosphate (CA4DP; CA4P), a fluorescent, water-soluble vascular disrupting agent (VDAs), is the pro-drug of CA4 able to induce vascular shutdown within tumors. Fosbretabulin Disodium是微管去稳定剂,能靶向损伤血管。

    More
  • Vinblastine EY1699

    Vinblastine能抑制nAChR,IC50为8.9 uM,还能抑制微管形成。

    More
  • Vincristine EY1704

    Vincristine通过与微管蛋白结合而抑制微管聚合,IC50为32 μM。

    More
  • Nocodazole EY1163

    Nocodazole是一种微管聚合的快速可逆抑制剂,也抑制Abl, Abl(E255K)和Abl(T315I),IC50分别为0.21 μM, 0.53 μM和0.64 μM。

    More
  • Epothilone B EY0324

    Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.

    More
  • Fosbretabulin Disodium EY0295

    Combretastatin A4 disodium phosphate (CA4DP; CA4P), a fluorescent, water-soluble vascular disrupting agent (VDAs), is the pro-drug of CA4 able to induce vascular shutdown within tumors. Fosbretabulin Disodium是微管去稳定剂,能靶向损伤血管。

    More
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